Key result
The cloning of the human renin receptor revealed that renin binding increases the catalytic efficiency of angiotensinogen conversion to angiotensin I fourfold and activates MAP kinases ERK1 and ERK2.
Population
Human kidney cDNA-phage library, immortalized human fetal mesangial cell line, and human normal kidney…
Comparison
Expression cloning of the human renin receptor… vs Control cells transfected with empty vector…
Design
Preclinical
Authors
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Caution against clinical use from animal data alone; leaves open receptor blockade as a novel RAS target for human trials.
The identification of the first renin/prorenin receptor demonstrates that renin has direct cellular effects independent of angiotensin II and that membrane binding significantly increases its catalytic efficiency.
Nguyen et al. (2002) studied this question. Renin receptor cloning and characterization was evaluated on Renin receptor identification and functional characterization. The cloning of the human renin receptor revealed that renin binding increases the catalytic efficiency of angiotensinogen conversion to angiotensin I fourfold and activates MAP kinases ERK1 and ERK2.
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