January 1, 2010Frontiers in Bioscience-EliteOpen Access

Role of pro renin receptor in cardiovascular cells from the aspect of signaling

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Population

Cardiovascular and kidney cells

Design

Review

Authors

HHHirofumi HitomKagawa University

Discussion

Member takes

Implication

Supports (pro)renin receptor as a potential therapeutic target beyond angiotensin II; leaves open clinical translation pending prospective studies.

Structured PICO

Population

Cardiovascular and kidney cells (cardiomyocytes, mesangial cells, podocytes, distal tubular cells, vascular endothelial cells, and vascular smooth muscle cells)

Intervention

(Pro)renin receptor activation by prorenin

Outcome

Intracellular signaling pathway activation

Prorenin mediates intracellular effects in cardiovascular and kidney cells via the (pro)renin receptor independently of angiotensin II, suggesting a novel mechanism for organ injury and potential therapeutic targets.

Cite This Study

Hirofumi Hitom (2010) studied this question.

synapsesocial.com/papers/6a80d5d11ece0ba82ce18bfa https://doi.org/10.2741/e185

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Implication

Supports (pro)renin receptor as a potential therapeutic target beyond angiotensin II; leaves open clinical translation pending prospective studies.

Role of pro renin receptor in cardiovascular cells from the aspect of signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of pro renin receptor in cardiovascular cells from the aspect of signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider