Why the study?
Does the handle region peptide prevent or improve nephropathy in experimental animal models of diabetes and hypertension?
Population
Experimental animal models of diabetes and essential hypertension and cultured cells
Comparison
Handle region peptide (decoy peptide) vs Vehicle or ACE inhibitors
Design
Review
Authors
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No change to nephropathy management; leaves open handle region peptide as a target for human trials.
Does the handle region peptide prevent or improve nephropathy in experimental animal models of diabetes and hypertension?
The (pro)renin receptor plays a key role in the breakdown of the glomerular filtration barrier, and its blockade with a handle region peptide offers a potential therapeutic target for hypertensive and diabetic nephropathy.
Ichihara et al. (2008) studied this question.
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