What question did this study set out to answer?

This study aims to evaluate the impact of spironolactone on serum apelin-12 levels in heart failure with reduced ejection fraction.

November 1, 2016Open Access

Effect of Spironolactone on Plasma Apelin-12 Levels in Patients with Chronic Systolic Heart Failure.

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Why the study?

Does spironolactone increase serum apelin-12 levels in outpatients with HFrEF?

Key Points

This study aims to evaluate the impact of spironolactone on serum apelin-12 levels in heart failure with reduced ejection fraction.
Eighty outpatients with heart failure with reduced ejection fraction were enrolled.
Patients received either standard heart failure therapy or spironolactone along with standard therapy.
Blood samples were collected to measure serum apelin-12 levels.
Plasma apelin-12 levels significantly higher in the spironolactone group (p < 0.001).
NT pro-BNP levels significantly lower in the spironolactone group (p < 0.001).
No association between baseline apelin-12 levels and clinical parameters.

Structured PICO

Does spironolactone increase serum apelin-12 levels in outpatients with HFrEF?

Population

80 outpatients with heart failure with reduced ejection fraction (HFrEF)

Intervention

Spironolactone 25 mg/daily added to standard heart failure therapy (ACEi/ARB, beta-blockers, loop diuretics, and anticoagulant or antiplatelet agents)

Comparator

Standard heart failure therapy without a mineralocorticoid receptor antagonist (MRA)

Outcome

Serum apelin-12 levelssurrogate

Spironolactone therapy in HFrEF is associated with increased levels of the cardioprotective peptide apelin-12 and reduced NT-proBNP.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Spironolactone-associated biomarker shifts in HFrEF merit prospective trials; leaves open effects on clinical outcomes.

Cite This Study

Topuz et al. (2016) studied this question.

synapsesocial.com/papers/6a20180d4f3426e554a1a6d5 https://doi.org/10.6515/acs20160115a

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Effect of Spironolactone on Plasma Apelin-12 Levels in Patients with Chronic Systolic Heart Failure.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effect of Spironolactone on Plasma Apelin-12 Levels in Patients with Chronic Systolic Heart Failure.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider