Key result
Computational prediction methods identified six evolutionarily conserved stem-loop structures in the NS5B-encoding region and two in the core gene of the hepatitis C virus.
Computational methods identified conserved RNA secondary structures in the coding regions of HCV, providing potential targets for future functional investigations.
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No immediate clinical implications for HCV; leaves open functional roles of these predicted structures.
Tuplin et al. (2002) studied Hepatitis C virus. Computational RNA secondary structure prediction was evaluated on Evolutionarily conserved stem-loop structures. Computational prediction methods identified six evolutionarily conserved stem-loop structures in the NS5B-encoding region and two in the core gene of the hepatitis C virus.
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