Key result
The cyclic GMP signaling pathway, activated via nitric oxide synthesis, is involved in NCAM-mediated neurite outgrowth and neuroprotection in hippocampal and dopaminergic neurons.
Population
hippocampal and dopaminergic neurons
Design
Preclinical
Authors
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Hypothesis-generating for cGMP-targeted neuroprotection; leaves open human translation pending clinical studies.
The study demonstrates that the cGMP signaling pathway, activated via NO synthesis, is involved in NCAM-mediated neurite outgrowth and neuroprotection.
Ditlevsen et al. (2007) studied Neuronal development and regeneration. Cyclic GMP signaling pathway was evaluated on Neurite outgrowth and neuroprotection. The cyclic GMP signaling pathway, activated via nitric oxide synthesis, is involved in NCAM-mediated neurite outgrowth and neuroprotection in hippocampal and dopaminergic neurons.
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