January 1, 1991Journal of the American Geriatrics Society
Forearm Blood Flow Response to Posture Change in the Very Old: Non‐Invasive Measurement by Venous Occlusion Plethysmography
Key result
Active standing elicited a significantly attenuated increase in forearm vascular resistance at 1 minute in healthy and impaired elderly subjects compared to young subjects.
Why the study?
Does the forearm vascular response to active standing differ between young, healthy old, and impaired elderly subjects?
Population
47 subjects including 18 healthy young, 10 healthy old, and 19 impaired elderly subjects
Comparison
Active standing (posture change) vs Comparison between young, healthy old, and…
Design
Cross-sectional
Follow-up
3 minutes
Authors
Discussion
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Implication
Attenuated forearm vasoconstriction on standing may heighten orthostatic intolerance risk in elderly; leaves open causal contribution to falls, needing prospective confirmation.
Study Design
Type
Cross-Sectional (n=47)
Structured PICO
Does the forearm vascular response to active standing differ between young, healthy old, and impaired elderly subjects?
P
Population
47 subjects including 18 healthy young, 10 healthy old, and 19 impaired elderly individuals assessed for forearm vascular response to active standing.
E
Exposure
Active standing (posture change)
C
Comparator
Comparison between young, healthy old, and impaired elderly groups
O
Outcome
Forearm vascular response (forearm blood flow and vascular resistance) at 1 and 3 minutes of standingsurrogate
The forearm vascular response to active standing is attenuated in many elderly subjects, which may impair adaptation to orthostatic stress.
Cite This Study
Lipsitz et al. (1991) conducted a cross-sectional in Aging and vulnerability to orthostatic hypotension (n=47). Active standing vs. Young subjects was evaluated on Forearm vascular resistance change at 1 minute of standing. Active standing elicited a significantly attenuated increase in forearm vascular resistance at 1 minute in healthy and impaired elderly subjects compared to young subjects.