Key result
Elevated high-sensitivity cardiac troponin T levels were significantly associated with a high risk for cardiovascular disease (Suita score ≥ 56) (OR 2.67; 95% CI 2.28–3.14; p < 0.001).
Why the study?
Elevation of hs-cTnT is associated with increased CVD risk, but whether it was detectable with NT-proBNP and related to CV risk factors in a general Japanese population remained to be determined.
Is high-sensitivity cardiac troponin T associated with NT-proBNP elevation and high cardiovascular risk in a general Japanese population?
Cohort (n=30,193)
Is high-sensitivity cardiac troponin T associated with NT-proBNP elevation and high cardiovascular risk in a general Japanese population?
In a general Japanese population, elevated hs-cTnT is associated with higher NT-proBNP and high cardiovascular risk scores, suggesting its utility as a biomarker for subclinical myocardial damage.
Purpose: Elevation of high-sensitivity cardiac troponin T (hs-cTnT) is associated with an increased risk of cardiovascular disease (CVD). This study determined whether hs-cTnT was detectable with N-terminal pro-b-type natriuretic peptide (NT-proBNP) and related to CV risk factors in a general Japanese population.Materials and methods: The Tohoku Medical Megabank Organization pooled individual participant data for a population-based cohort study in the Iwate prefecture (n = 30,193, age = 60.2 ± 11.5 year).Results: Hs-cTnT levels were higher in participants with hypertension, diabetes mellitus than in participants without these conditions (all ps < 0.001). Logistic regression analysis demonstrated that NT-proBNP was strongly associated with elevation of hs-cTnT (OR = 3.35, 95% CI = 2.90–3.89, p < 0.001). The receiver operating characteristic curve analysis showed that hs-cTnT was one of useful biomarker for the differentiation of high risk for CVD (the Suita score ≥ 56) from a general population. Logistic regression analysis demonstrated hs-cTnT levels were related to the CVD high risk group (OR = 2.67, 95% CI = 2.28–3.14, p < 0.001).Conclusions: Hs-cTnT levels are associated with elevation of NT-proBNP and high Suita score, which suggests that elevated hs-cTnT is related to subclinical myocardial damage and indicates CV risk.
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Takahashi et al. (2019) conducted a cohort in General population (n=30,193). High-sensitivity cardiac troponin T (hs-cTnT) elevation vs. Lower hs-cTnT levels was evaluated on High risk for cardiovascular disease (Suita score ≥ 56) (OR 2.67, 95% CI 2.28-3.14, p=< 0.001). Elevated high-sensitivity cardiac troponin T levels were significantly associated with a high risk for cardiovascular disease (Suita score ≥ 56) (OR 2.67; 95% CI 2.28–3.14; p < 0.001).
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