Key result
Antihypertensive discontinuation resolves delirious mania following blood pressure normalization.
Why the study?
Does the discontinuation of antihypertensive medications and normalization of blood pressure improve symptoms of delirious mania in an elderly patient with a history of bipolar disorder?
Case Report (n=1)
No
Does the discontinuation of antihypertensive medications and normalization of blood pressure improve symptoms of delirious mania in an elderly patient with a history of bipolar disorder?
This case highlights the potential for antihypertensive medications and subsequent hypotension to trigger delirious mania in elderly patients with a history of bipolar disorder.
May warrant hypotension screening in bipolar mania; single case report leaves open causality and need for controlled confirmation.
Delirious mania is a severe but often underrecognized syndrome characterized by rapid onset of delirium, mania, and psychosis, not associated with a prior toxicity, physical illness, or mental disorder. We discuss the case of a delirious mania potentially triggered and maintained by a systemic hypotension induced by antihypertensive drugs. Symptoms recovered completely after the discontinuation of antihypertensive medications and the normalization of blood pressure levels.
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Carbone et al. (2017) conducted a case report in Delirious mania associated with Bipolar I Disorder (n=1). Antihypertensive medications (bisoprolol, alfuzosin, enalapril, hydrochlorothiazide) was evaluated on Resolution of delirious mania symptoms. Discontinuation of antihypertensive medications and the normalization of blood pressure levels led to the complete recovery from delirious mania symptoms.
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