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June 17, 2026Case Reports in PsychiatryOpen Access

Unraveling Protracted Neuropsychiatric Symptoms in a Patient With Altered Post‐Bariatric Pharmacokinetics: A Diagnostic Puzzle

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Authors

AAAkbar AliMarshall UniversityCPChristopher E. PottsMarshall UniversityDMDakota MayMarshall University

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Implication

Case report demonstrates complex neuropsychiatric symptoms post-serotonin syndrome, highlighting diagnostic challenges in altered pharmacokinetics.

Key Points

  • To present a case of serotonin toxicity evolving into a persistent neuropsychiatric syndrome, complicating diagnoses.
  • Case report of a 61‐year‐old male post-gastric sleeve surgery with MDD.
  • Examined interactions between fluoxetine, buspirone, and linezolid leading to acute serotonin syndrome.
  • Conducted genetic testing and multidisciplinary evaluations for differential diagnosis.
  • Acute autonomic instability resolved after stopping serotonergic medications; subacute neurological deficits emerged.
  • Diagnosis included FND, PNES, and chronic migraine, with an SLC6A4 polymorphism identified.
  • Management challenges noted due to medication sensitivity and parasomnias during vilazodone trial.

Cite This Study

Ali et al. (2026) studied this question.

synapsesocial.com/papers/6a323c29d50b63ecad20668ehttps://doi.org/10.1155/crps/8340699
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