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June 17, 2026Case Reports in PsychiatryOpen Access

Unexpected Improvement of Obsessive–Compulsive Disorder Symptoms Following the Mistaken Prescription of Clomiphene: A Novel Perspective on Hormonal Influences in OCD

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Authors

SHSeyed Hamzeh HosseiniImam Khomeini HospitalBABehnam AbbasiMazandaran University of Medical SciencesFKFatemeh Abedian KenariMazandaran University of Medical Sciences

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Implication

Case report shows unexpected improvement of OCD symptoms with clomiphene in a patient, indicating potential hormonal influences.

Key Points

  • This case examines the unexpected improvement in OCD symptoms due to a mistaken prescription of clomiphene instead of clomipramine.
  • A 50-year-old woman with OCD and history of major depressive disorder was treated with clomiphene 25 mg/day for 12 weeks after a prescription error.
  • Pre-treatment involved sertraline and clonazepam, with ineffective results prior to clomiphene administration.
  • Y-BOSC scores were assessed to quantify symptom changes.
  • The patient experienced a reduction in Y-BOCS score from 23 to ~7, indicating a complete remission of OCD symptoms.
  • No adverse effects were reported during clomiphene treatment.
  • Subsequent reintroduction of clomipramine did not reproduce the same improvement.

Cite This Study

Hosseini et al. (2026) studied this question.

synapsesocial.com/papers/6a323e36d50b63ecad2077efhttps://doi.org/10.1155/crps/4931083
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Psychological side-effects of clomiphene citrate and human menopausal gonadotrophin2005 · 79 citations
  2. 2Neural and Hormonal Control of Sexual Behavior2020 · 154 citations
  3. 3The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders2020 · 216 citations
  4. 4World Medical Association Declaration of Helsinki2024 · 1,530 citations
  5. 5Criterion Validity of the Yale-Brown Obsessive-Compulsive Scale Second Edition for Diagnosis of Obsessive-Compulsive Disorder in Adults2018 · 50 citations