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June 13, 2026Case Reports in PsychiatryOpen Access

Obsessive‐Compulsive Symptoms Associated With Bupropion Treatment: A Case Series

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Authors

JBJosé Alfonso Ontiveros-Sánchez de la BarqueraLGLuis Alberto De La Garza GarcíaGSGuillermo Sánchez‐Torres

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Overview

Case series reveals onset of obsessive-compulsive symptoms in patients treated with bupropion, indicating a potential side effect.

Key Points

  • To investigate the occurrence of obsessive-compulsive symptoms associated with bupropion treatment in depressed patients.
  • Presented four cases of patients with affective disorders experiencing obsessive-compulsive symptoms after bupropion initiation.
  • Utilized the Yale–Brown obsessive–compulsive scale and clinical global impression–severity scale for symptom evaluation.
  • Documented symptom progression and remission upon discontinuation of bupropion.
  • All patients experienced a notable increase in obsessive-compulsive symptoms after starting bupropion.
  • Complete remission of symptoms was observed after discontinuation of bupropion treatment.
  • Patients had no previous history of obsessive ideation or compulsion.

Cite This Study

Barquera et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f05884ahttps://doi.org/10.1155/crps/8097103
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