Key result
Levosimendan decreased isovolumic relaxation time by 23% (P<0.001) and increased cardiac output by 28% (P<0.001) compared with placebo in patients after aortic valve replacement.
Why the study?
Does levosimendan improve left ventricular relaxation and early filling in patients with LV hypertrophy after aortic valve replacement for aortic stenosis?
Population
23 patients with left ventricular (LV) hypertrophy after aortic valve replacement for aortic stenosis
Comparison
Levosimendan infusion (0.1 and 0.2 microg x kg x… vs Placebo infusion, with heart rate and mean…
Design
RCT, randomized, blinded
Authors
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Supports levosimendan for post-AVR hemodynamic optimization in LV hypertrophy; extends RCT evidence of lusitropic effects.
RCT (n=23)
blinded
randomized
Does levosimendan improve left ventricular relaxation and early filling in patients with LV hypertrophy after aortic valve replacement for aortic stenosis?
p-value: p=<0.001
Levosimendan exerts a direct positive lusitropic effect, shortening isovolumic relaxation time and improving LV filling in patients with LV hypertrophy after aortic valve replacement.
Jörgensen et al. (2008) conducted an RCT in Left ventricular hypertrophy after aortic valve replacement for aortic stenosis (n=23). Levosimendan vs. placebo was evaluated on Isovolumic relaxation time (p=<0.001). Levosimendan decreased isovolumic relaxation time by 23% (P<0.001) and increased cardiac output by 28% (P<0.001) compared with placebo in patients after aortic valve replacement.
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