Key result
In an in vitro model, left ventricular diastolic flow propagation velocity showed excellent correlations with stroke volume (r = 0.98) and LV compliance (r = 0.94).
Effect estimate: r = 0.98
p-value: p=<0.0001
In an in vitro model, left ventricular diastolic flow propagation velocity strongly correlates with stroke volume, LV compliance, and heart rate, providing mechanistic insights into early diastolic LV filling.
Should not yet inform clinical diastolic assessment; hypothesis-generating for LV filling mechanics pending in vivo data.
BACKGROUND: Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography. METHODS: An in vitro LV model used to simulate LV diastolic inflow with Vp measured under conditions of varying: 1) Stroke volume, 2) heart rate (HR), 3) LV volume, 4) LV compliance, and 5) transmitral flow (TMF) waveforms (Type 1: constant low diastasis flow and Type 2: no diastasis flow). RESULTS: Univariate analysis revealed excellent correlations of Vp with stroke volume (r = 0.98), LV compliance (r = 0.94), and HR with Type 1 TMF (r = 0.97). However, with Type 2 TMF, HR was not associated with Vp. LV volume was not related to Vp under low compliance, but inversely related to Vp under high compliance conditions (r = -0.56). CONCLUSION: These in vitro findings may help elucidate the relationship of hemodynamic parameters to early diastolic LV filling.
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Ogawa et al. (2005) studied Left ventricular diastolic flow propagation velocity. Hemodynamic parameter variation (stroke volume, heart rate, LV volume, LV compliance) was evaluated on Correlation of flow propagation velocity (Vp) with stroke volume (r = 0.98, p=<0.0001). In an in vitro model, left ventricular diastolic flow propagation velocity showed excellent correlations with stroke volume (r = 0.98) and LV compliance (r = 0.94).
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