Key result
Desflurane decreased systemic vascular resistance and total arterial resistance without altering compliance, whereas sevoflurane increased compliance and characteristic aortic impedance.
Why the study?
Does desflurane or sevoflurane alter left ventricular afterload in chronically instrumented dogs?
Population
Chronically instrumented dogs (n=8)
Comparison
Desflurane or sevoflurane at 1.1, 1.3, 1.5, and… vs Conscious state under steady-state conditions
Design
Preclinical
Authors
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Differential afterload effects in dogs are hypothesis-generating; human studies needed before clinical translation.
Does desflurane or sevoflurane alter left ventricular afterload in chronically instrumented dogs?
Desflurane and sevoflurane produce substantially different effects on left ventricular afterload in dogs, with desflurane primarily decreasing arteriolar resistance and sevoflurane altering the mechanical properties of the aorta.
Lowe et al. (1996) studied this question. Desflurane and sevoflurane vs. Conscious state (control) was evaluated on Quantitative indices of left ventricular afterload (Zin, Zc, R, C). Desflurane decreased systemic vascular resistance and total arterial resistance without altering compliance, whereas sevoflurane increased compliance and characteristic aortic impedance.
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