Why the study?
Does desflurane preserve hemodynamics better than sevoflurane or isoflurane in a rat model of pressure-overload right ventricular hypertrophy?
Population
28 rats randomly assigned to a control or a monocrotaline group to induce pressure-overload right…
Comparison
Dose-responses to desflurane, sevoflurane, and… vs Comparison between the three halogenated…
Design
Preclinical, randomly assigned
Follow-up
4 weeks
Authors
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May favor desflurane in experimental RV hypertrophy; leaves open translation to human perioperative practice.
Does desflurane preserve hemodynamics better than sevoflurane or isoflurane in a rat model of pressure-overload right ventricular hypertrophy?
In a rat model of pressure-overload RV hypertrophy, desflurane better preserved hemodynamics and RV contractility compared to sevoflurane and isoflurane.
Blaudszun et al. (2012) studied this question.
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