Key result
Digoxin significantly augmented pressor responsiveness to both norepinephrine and angiotensin in normal men, without significantly affecting the steady state baroreceptor-heart rate reflex.
Why the study?
Does digoxin alter blood pressure, the renin-aldosterone axis, and pressor responses to norepinephrine and angiotensin in normal men?
Population
6 normal men after pretreatment with dexamethasone
Design
Other
Follow-up
4 days
Authors
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Should not change digoxin use in patients; leaves open whether endogenous digitalis-like factors regulate blood pressure.
Does digoxin alter blood pressure, the renin-aldosterone axis, and pressor responses to norepinephrine and angiotensin in normal men?
Digoxin augments pressor responsiveness to norepinephrine and angiotensin in normal men, suggesting endogenous digitalis-like factors may influence arterial blood pressure control.
GUTHRIE P. GORDON (1984) studied Healthy volunteers (n=6). Digoxin was evaluated on Blood pressure, the renin-aldosterone axis, and pressor and steroidogenic responses to graded norepinephrine, angiotensin, and ACTH infusions. Digoxin significantly augmented pressor responsiveness to both norepinephrine and angiotensin in normal men, without significantly affecting the steady state baroreceptor-heart rate reflex.
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