Key result
Simultaneous administration of digoxin (6 mg/kg/day) significantly reduced systolic blood pressure to 120±3 mmHg on Day 1 compared to 148±2 mmHg in rats given norepinephrine alone (p<0.01).
Why the study?
Does digoxin alter blood pressure responses to norepinephrine, angiotensin II, and vasopressin in conscious rats?
Does digoxin alter blood pressure responses to norepinephrine, angiotensin II, and vasopressin in conscious rats?
Short-term digoxin treatment has variable effects on blood pressure in rats depending on the specific vasoconstrictor used to induce hypertension.
Digoxin may blunt norepinephrine-induced hypertension in rats; leaves open effects on other vasoconstrictors and any human relevance.
YASUJIMA, M., ABE, K., TANNO, M., KOHZUKI, M., KANAZAWA, M., YOSHIDA, K., OMATA, K., SATO, M., TAKEUCHI, K., HIWATARI, M., SATO, T. and YOSHINAGA, K. Effects of Digoxin on Blood Pressure Responses to Norepinephrine, Angiotensin II and Vasopressin in Conscious Rats. Tohoku J. Exp. Med., 1990, 162 (3), 203 -212-To investigate the interaction of cardiac glycosides with vasoconstrictors, we examined the effects of short term treatment with the cardiac glycoside digoxin (6mg/kg/day, i.p., for 6 days) in rats made hypertensive by chronic infusion of norepinephrine (NE), angiotensin II (A II) or vasopressin (VP). When digoxin was administered simultaneously with NE at 1.8mg/kg/day (i.p.) by use of osmotic minipumps in conscious rats, systolic blood pressure decreased to 120±3mmHg on Day 1 whereas it rose to 148±2mmHg in rats given NE alone (p<0.01). The antihypertensive effect of digoxin was sustained for the entire experimental period and was not associated with any change in urinary sodium excretion. When the same dose of digoxin was administered simultaneously with A II at 900μg/kg/day (i.p.) in conscious rats, systolic blood pressure rose to a greater extent than in those given A II alone. The administration of digoxin had no effect an the blood pressure elevation induced by chronic infusion of VP at a rate of 7.2U/kg/day (i.p.). It is concluded that short term treatment with digoxin has a variety of effects on blood pressure in rats; pressor, depressor, or is no effects depending upon vasoconstrictor used.
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Yasujima et al. (1990) studied Hypertension (induced by vasoconstrictors). Digoxin vs. Norepinephrine alone was evaluated on Systolic blood pressure on Day 1 (p=<0.01). Simultaneous administration of digoxin (6 mg/kg/day) significantly reduced systolic blood pressure to 120±3 mmHg on Day 1 compared to 148±2 mmHg in rats given norepinephrine alone (p<0.01).
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