Key result
Insulin-like growth factor-binding proteins (IGFBPs) function to modulate IGF actions, facilitate IGF storage in extracellular matrices, and exert IGF effects on target cells.
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Design
Review
IGFBP functions in IGF modulation are summarized; leaves open targeted cardiovascular studies before clinical adoption.
I. Introduction II. Characteristics of the IGFBPs III. Target Cell Actions of the IGFBPs A. To modulate IGF actions B. To facilitate storage of IGFs in extracellular matrices C. To exert IGF
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Rajaram et al. (1997) studied this question. Insulin-like growth factor-binding proteins (IGFBPs) function to modulate IGF actions, facilitate IGF storage in extracellular matrices, and exert IGF effects on target cells.
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