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October 1, 1993Experimental Biology and Medicine

Insulin is the primary regulator of IGFBP-1 expression, rapidly inhibiting its transcription, while cortisol, glucagon, and cAMP stimulate its production; IGFBP-1 inhibits IGF-mediated mitogenic and metabolic actions.

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PLPhillip LeeCCCheryl A. ConoverDPDavid R. Powell

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Overview

May inform glucose counterregulation mechanisms; leaves open IGFBP-1 as biomarker or target pending prospective trials.

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Cite This Study

Lee et al. (1993) studied this question.

synapsesocial.com/papers/6a700df6a7fbea1e4407ee24https://doi.org/10.3181/00379727-204-43630
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