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March 3, 2020Frontiers in EndocrinologyOpen Access

IGFBP-5 is a multifunctional protein with the ability to act as a molecular switch to conditionally regulate IGF signaling.

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Why the study?

Despite its evolutionary conservation and broad biological activities, knockout of IGFBP-5 in mice yields only a negligible phenotype, prompting research into its context-dependent roles.

Design

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Authors

CDCunming DuanJAJohn B. Allard

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Overview

IGFBP-5's conserved breadth may guide cardiometabolic hypotheses; leaves open targeted trials before practice implications.

Key Points

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Cite This Study

Duan et al. (2020) studied this question.

synapsesocial.com/papers/6a6fdaaa75498292b7093abahttps://doi.org/10.3389/fendo.2020.00100
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IGF‐independent effects of insulin‐like growth factor binding protein‐5 ( Igfbp5) in vivo2009 · 70 citations
  2. 2Regulation and Function of Insulin-Like Growth Factor-Binding Protein-11993 · 391 citations
  3. 340 YEARS OF IGF1: IGF-binding proteins2017 · 261 citations
  4. 4IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms2002 · 447 citations
  5. 5Evidence That IGF Binding Protein-5 Functions as a Ligand-Independent Transcriptional Regulator in Vascular Smooth Muscle Cells2004 · 92 citations