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March 9, 2004Circulation Research

IGFBP-5 localizes to the VSMC nucleus via its C-domain and possesses strong, IGF-independent transcription-regulatory activity in its N-domain.

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Population

Vascular smooth muscle cells (VSMCs) and human aorta cDNA library

Comparison

Analysis of IGFBP-5 nuclear localization and… vs IGFBP-4-EGFP and unmutated controls

Design

Preclinical

Authors

QXQijin XuSLShenghua LiYZYang Zhao

Discussion

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Overview

May inform VSMC regulatory mechanisms; leaves open translation to human vascular disease.

Structured PICO

P
Population
Vascular smooth muscle cells (VSMCs) and human aorta cDNA library
I
Intervention
Analysis of IGFBP-5 nuclear localization and transactivation activity using IGFBP-4/5 chimeras, point mutants, and yeast two-hybrid screening
C
Comparator
IGFBP-4-EGFP and unmutated controls
O
Outcome
Nuclear localization and transactivation activity of IGFBP-5surrogate

IGFBP-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells, providing a molecular basis for its IGF-independent actions.

Cite This Study

Xu et al. (2004) studied this question.

synapsesocial.com/papers/6a76ae659ba60942f10619fahttps://doi.org/10.1161/01.res.0000124761.62846.df
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease2020 · 114 citations
  2. 2Several Acidic Amino Acids in the N-domain of Insulin-like Growth Factor-binding Protein-5 Are Important for Its Transactivation Activity2006 · 52 citations
  3. 3IGF‐independent effects of insulin‐like growth factor binding protein‐5 ( Igfbp5) in vivo2009 · 70 citations
  4. 4Insulin-like Growth Factor-I (IGF-I) Regulates IGF-binding Protein-5 Synthesis through Transcriptional Activation of the Gene in Aortic Smooth Muscle Cells2021 · 12 citations
  5. 5Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation2013 · 17 citations