Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2013Korean Journal of Physiology and PharmacologyOpen Access

IGFBP-5 is upregulated in vascular smooth muscle cells of spontaneously hypertensive rats and stimulates excessive cell proliferation via the ERK1/2 MAPK signaling pathway.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does IGFBP-5 regulate excessive vascular smooth muscle cell proliferation in spontaneously hypertensive rats?

Population

Aortic vascular smooth muscle cells isolated from 24-week-old male spontaneously hypertensive rats and…

Comparison

Recombinant IGFBP-5, IGFBP-5 siRNA, Angiotensin… vs Untreated cells, control siRNA, and normotensive…

Design

Preclinical

Key result

IGFBP-5 is upregulated in vascular smooth muscle cells of spontaneously hypertensive rats and stimulates excessive cell proliferation via the ERK1/2 MAPK signaling pathway.

Authors

DLDong Hyup LeeJKJung Eun KimYKYoung Jin Kang

Discussion

Loading...

Member takes

Overview

May implicate IGFBP-5 in hypertensive vascular remodeling; hypothesis-generating and requires human validation before any clinical consideration.

Structured PICO

Does IGFBP-5 regulate excessive vascular smooth muscle cell proliferation in spontaneously hypertensive rats?

P
Population
In vitro study using aortic vascular smooth muscle cells isolated from 24-week-old male spontaneously hypertensive rats and age-matched normotensive Wistar Kyoto rats.
I
Intervention
Recombinant IGFBP-5, IGFBP-5 siRNA, Angiotensin II, IGF-1, and MEK1/2 inhibitors (PD98059, U0126)
C
Comparator
Untreated cells, control siRNA, and normotensive WKY VSMCs
O
Outcome
VSMC proliferation and ERK1/2 phosphorylationsurrogate

Main Result

p-value: p=<0.001

IGFBP-5 is up-regulated in VSMCs of hypertensive rats and promotes excessive cell proliferation via the ERK1/2 MAPK pathway, highlighting a potential mechanism for vascular remodeling in hypertension.

Limitations

  • In vitro study design
  • Further studies are needed to establish the cause and effect association between IGFBP-5 interaction with ERK1/2 phosphorylation and cell proliferation in vivo

Cite This Study

Lee et al. (2013) studied Hypertension (Preclinical). Recombinant IGFBP-5 and IGFBP-5 siRNA vs. Control (WKY VSMCs or control siRNA) was evaluated on Vascular smooth muscle cell proliferation (p=<0.001). IGFBP-5 is upregulated in vascular smooth muscle cells of spontaneously hypertensive rats and stimulates excessive cell proliferation via the ERK1/2 MAPK signaling pathway.

synapsesocial.com/papers/6a98ed177384e28de71fef25https://doi.org/10.4196/kjpp.2013.17.2.157
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-Like Growth Factor Binding Protein-4 Expression Is Decreased by Angiotensin II and Thrombin in Rat Aortic Vascular Smooth Muscle Cells2000 · 16 citations
  2. 2Insulin-like growth factor binding proteins-2 to -6 are expressed by human vascular smooth muscle cells1999 · 11 citations
  3. 3Regulation of insulin‐like growth factor (IGF) binding protein‐2 synthesis and degradation by platelet‐derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells1995 · 32 citations
  4. 4IGFBP5 mediates high glucose-induced cardiac fibroblast activation2013 · 44 citations
  5. 5Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis2024 · 10 citations