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November 1, 1999Journal of EndocrinologyOpen Access

Insulin-like growth factor binding proteins-2 to -6 are expressed by human vascular smooth muscle cells

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Key result

Human vascular smooth muscle cells express IGFBPs-2 to -6, and exogenous IGFBPs-1, -3, and -4 inhibited IGF-I-induced DNA synthesis.

Population

Human vascular smooth muscle cells (hVSMCs) cultured from human renal arteries

Design

Preclinical

Authors

PAPer AnderssonLinköping UniversityTGThomas GustafssonHeart Failure & TransplantHAH. J. ArnqvistLinköping University

Discussion

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Implication

Hypothesis-generating for IGFBP modulation of vascular IGF-I signaling; in vivo studies needed before any clinical consideration.

Structured PICO

P
Population
Human vascular smooth muscle cells (hVSMCs) cultured from human renal arteries
I
Intervention
Serum starvation for 48 h; Exogenous IGFBPs-1 to -6 (50 ng/ml)
O
Outcome
Expression and secretion of insulin-like growth factor binding proteins (IGFBPs-1 to -6) mRNA and peptides; DNA synthesis induced by 1 nM IGF-Isurrogate

Human vascular smooth muscle cells locally express IGFBPs-2 to -6, which can modulate IGF-I-induced DNA synthesis.

Cite This Study

Andersson et al. (1999) studied this question. Exogenous IGFBPs was evaluated on DNA synthesis induced by 1 nM IGF-I. Human vascular smooth muscle cells express IGFBPs-2 to -6, and exogenous IGFBPs-1, -3, and -4 inhibited IGF-I-induced DNA synthesis.

synapsesocial.com/papers/6a94d869c163d75667fa5580https://doi.org/10.1677/joe.0.1630281
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-like growth factor binding protein production by bovine and human vascular smooth muscle cells: production of insulin-like growth factor binding protein-6 by human smooth muscle.1996 · 18 citations
  2. 2Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II.1995 · 127 citations
  3. 3Cloning and sequence determination of bovine insulin‐like growth factor binding protein‐2 (IGFBP‐2): Comparison of its structral and functional properties with IGFBP‐11992 · 112 citations
  4. 4JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM1953 · 3,806 citations
  5. 5Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells.1996 · 60 citations