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March 30, 2009The FASEB Journal

Both wild-type and mutant Igfbp5 significantly inhibited growth, but only wild-type IGFBP-5 rescued the lethal phenotype induced by excess IGF-II in type 2 receptor-null mice.

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Population

Mice (including type 2 receptor-null mice)

Design

Preclinical

Authors

GTGyanendra TripathiDSDerviş A. SalihADAnja C. Drozd

Discussion

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Overview

Supports IGF-independent actions of IGFBP-5 in murine development; leaves open therapeutic implications for IGF-related human pathologies.

Structured PICO

P
Population
Mice (including type 2 receptor-null mice)
I
Intervention
Overexpression of wild-type Igfbp5 or an N-terminal mutant Igfbp5 with negligible IGF binding affinity
O
Outcome
Growth inhibition and rescue of lethal phenotype

The study suggests significant IGF-independent actions for IGFBP-5 during development and its potential to inhibit IGF activity in pathologies.

Cite This Study

Tripathi et al. (2009) studied this question.

synapsesocial.com/papers/6a896145a7eee2293bcafb6bhttps://doi.org/10.1096/fj.08-114124
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Also Consider

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