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January 1, 2001Journal of Clinical InvestigationOpen Access

Treatment with IGFBP-5 increased proliferation and ALP activity in vitro, and a single local injection increased ALP activity and osteocalcin levels in vivo in IGF-I KO mice, comparable to effects in C3H mice.

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Population

IGF-I knockout (KO) mice, osteoblast clones derived from IGF-I KO mice, and C3H mice

Comparison

Recombinant human IGFBP-5 vs IGF-I, IGFBP-4, or untreated controls

Design

Preclinical

Authors

NMNaohisa MiyakoshiCRCharmaine RichmanYKYuji Kasukawa

Discussion

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Overview

May stimulate bone formation via IGF-independent pathways in mice; leaves open clinical relevance for osteoporosis treatment.

Structured PICO

P
Population
IGF-I knockout (KO) mice, osteoblast clones derived from IGF-I KO mice, and C3H mice
I
Intervention
Recombinant human IGFBP-5 (in vitro treatment of serum-free cultures, and in vivo single local injection to the outer periosteum of the parietal bone)
C
Comparator
IGF-I, IGFBP-4, or untreated controls
O
Outcome
Cell proliferation, alkaline phosphatase (ALP) activity, and osteocalcin levelssurrogate

IGFBP-5 functions as a growth factor stimulating bone formation via an IGF-independent mechanism.

Cite This Study

Miyakoshi et al. (2001) studied this question.

synapsesocial.com/papers/6a7d4f4bb62e30e3311cc97ehttps://doi.org/10.1172/jci10459
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Also Consider

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  1. 1IGF‐independent effects of insulin‐like growth factor binding protein‐5 ( Igfbp5) in vivo2009 · 70 citations
  2. 2Paradoxical Actions of Endogenous and Exogenous Insulin-like Growth Factor-binding Protein-5 Revealed by RNA Interference Analysis2004 · 65 citations
  3. 3IGFBP-2 Directly Stimulates Osteoblast Differentiation2014 · 63 citations
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  5. 5Evidence That IGF Binding Protein-5 Functions as a Ligand-Independent Transcriptional Regulator in Vascular Smooth Muscle Cells2004 · 92 citations