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August 1, 2003Journal of Endocrinology

IGF-binding protein-4: biochemical characteristics and functional consequences

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Key result

IGFBP-4 binds IGF-I and IGF-II with similar affinities and inhibits their actions under almost all in vitro and in vivo conditions, with biological significance in various physiological and pathological states.

Design

Review

Authors

RZRu ZhouDDDaniela DiehlAHAndreas Hoeflich

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Overview

Alerts clinicians to IGFBP-4 effects in IGF-related states; extends literature but leaves therapeutic targeting unresolved.

PICO

E
Exposure / Comparator
IGFBP-4

This review provides a comprehensive overview of the biochemical characteristics and functional roles of IGFBP-4 in various physiological and pathological processes.

Cite This Study

Zhou et al. (2003) reported a review. IGFBP-4 was evaluated. IGFBP-4 binds IGF-I and IGF-II with similar affinities and inhibits their actions under almost all in vitro and in vivo conditions, with biological significance in various physiological and pathological states.

synapsesocial.com/papers/6a6f3ca8e5469ee92be042c1https://doi.org/10.1677/joe.0.1780177
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