August 1, 1987Journal of Applied Physiology

Operation Everest II: preservation of cardiac function at extreme altitude

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Why the study?

Does extreme, chronic hypoxemia impair cardiac rate and pump functions in healthy subjects?

Population

8 subjects undergoing a 40-day simulated climb of Mt. Everest

Comparison

40-day simulated climb of Mt. Everest with… vs Baseline measurements at sea level and…

Design

Cohort

Follow-up

40 days

Authors

JRJohn Τ. ReevesRegeneron (United States)BGBertron Μ. GrovesVascular / Pulmonary Vascular JSJ. R. SuttonImperial College London

Discussion

Member takes

Implication

Extreme chronic hypoxemia may preserve cardiac output in healthy subjects; hypothesis-generating for adaptation and requires validation in patients.

Structured PICO

Does extreme, chronic hypoxemia impair cardiac rate and pump functions in healthy subjects?

Population

8 subjects (5 with complete resting and exercise measurements) undergoing a 40-day simulated climb of Mt. Everest

Intervention

40-day simulated climb of Mt. Everest with extreme, chronic hypoxemia (8,840 m, barometric pressure of 240 Torr, inspiratory O2 pressure of 43 Torr)

Comparator

Baseline measurements at sea level (760 Torr) and intermediate simulated altitudes (347 Torr, 282 Torr), as well as O2 breathing at extreme altitude

Outcome

Cardiac function (heart rate, cardiac output, stroke volume, and ventricular filling pressures) at rest and during exercisesurrogate

Extreme chronic hypoxemia during a simulated Mt. Everest climb does not significantly impair intrinsic cardiac pump function or heart rate.

Cite This Study

Reeves et al. (1987) studied this question.

synapsesocial.com/papers/6a20256df00dea096ea1abea https://doi.org/10.1152/jappl.1987.63.2.531

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Implication

Extreme chronic hypoxemia may preserve cardiac output in healthy subjects; hypothesis-generating for adaptation and requires validation in patients.

Operation Everest II: preservation of cardiac function at extreme altitude

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Operation Everest II: preservation of cardiac function at extreme altitude

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider