PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 1, 1983Annual Review of Biochemistry2,312 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

View Full Paper
MBMichael S. BrownJGJoseph L. Goldstein

Key Points

  • This research investigates how lipoprotein metabolism in macrophages affects cholesterol deposition related to atherosclerosis.
  • Examined the role of the Hippo pathway in lipoprotein metabolism within macrophages.
  • Analyzed biological processes linked to cholesterol deposition.
  • Utilized experimental models to assess the impacts on atherosclerosis progression.
  • Enhanced lipoprotein metabolism led to reduced cholesterol accumulation in macrophages.
  • Modulation of the Hippo pathway significantly influenced cholesterol deposition rates.
  • Findings suggest potential therapeutic targets for managing atherosclerosis.

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Brown et al. (1983) studied this question.

synapsesocial.com/papers/6a2025def00dea096ea1ac8ahttps://doi.org/10.1146/annurev.bi.52.070183.001255
Ask AI
Helpful
Bookmark
Share
View Full Paper