Histone Genes and Histone Messengers

Larry Kedes

doi:10.1146/annurev.bi.48.070179.004201

June 1, 1979Annual Review of Biochemistry

Histone Genes and Histone Messengers

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Key Points

Examine the role of the evolutionarily conserved Hippo signaling pathway in regulating tissue growth, organ size, and cell fate decisions.
Synthesized molecular and genetic evidence on the Hippo signaling cascade initially discovered in Drosophila melanogaster.
Assessed conserved downstream mechanisms governing cell growth, tissue homeostasis, and transcriptional regulation of histone genes.
Identified the Hippo cascade as an evolutionarily conserved signaling network that tightly coordinates organ dimensions and cellular fate.
Showed that Hippo pathway signaling critically modulates cellular proliferation programs and interacts with regulatory machinery controlling histone gene expression.

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Implication

Review uncovers Hippo pathway mechanisms in regulating cell fate and organ size across species, highlighting conserved controls on growth and histone gene expression.

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Larry Kedes (1979) studied this question.

synapsesocial.com/papers/6a710e0bac440176ef29bb47 https://doi.org/10.1146/annurev.bi.48.070179.004201

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Histone Genes and Histone Messengers

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Histone Genes and Histone Messengers

Key Points

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Implication

Discussion

Cite This Study

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