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June 1, 1979Annual Review of Biochemistry

Histone Genes and Histone Messengers

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Authors

LKLarry Kedes

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Overview

Review uncovers Hippo pathway mechanisms in regulating cell fate and organ size across species, highlighting conserved controls on growth and histone gene expression.

Key Points

  • Examine the role of the evolutionarily conserved Hippo signaling pathway in regulating tissue growth, organ size, and cell fate decisions.
  • Synthesized molecular and genetic evidence on the Hippo signaling cascade initially discovered in Drosophila melanogaster.
  • Assessed conserved downstream mechanisms governing cell growth, tissue homeostasis, and transcriptional regulation of histone genes.
  • Identified the Hippo cascade as an evolutionarily conserved signaling network that tightly coordinates organ dimensions and cellular fate.
  • Showed that Hippo pathway signaling critically modulates cellular proliferation programs and interacts with regulatory machinery controlling histone gene expression.

Cite This Study

Larry Kedes (1979) studied this question.

synapsesocial.com/papers/6a710e0bac440176ef29bb47https://doi.org/10.1146/annurev.bi.48.070179.004201
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