Key result
Chronic electrical activation of the carotid baroreflex is an innovative nonpharmacological approach for resistant hypertension, with clinical trials currently underway.
Why the study?
Does chronic electrical activation of the carotid baroreflex reduce arterial pressure in resistant hypertension?
Does chronic electrical activation of the carotid baroreflex reduce arterial pressure in resistant hypertension?
Chronic electrical activation of the carotid baroreflex is an emerging nonpharmacological approach for resistant hypertension with promising preclinical results.
This article reviews the history and current status of an innovative nonpharmacological approach for the treatment of resistant hypertension - chronic electrical activation of the afferent limb of the carotid baroreflex. Recent studies in both normotensive and hypertensive canine models have unambiguously demonstrated sustained and clinically relevant reductions in arterial pressure and sympathetic activity in the course of prolonged baroreflex activation. Clinical trials designed to evaluate the efficacy and safety of this therapy in patients with resistant hypertension are now underway in both Europe and the USA.
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Sica et al. (2006) conducted a review in Resistant hypertension. Chronic electrical activation of the afferent limb of the carotid baroreflex was evaluated. Chronic electrical activation of the carotid baroreflex is an innovative nonpharmacological approach for resistant hypertension, with clinical trials currently underway.
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