Key result
Electrical activation of the carotid baroreflex using a novel implantable device reduced office systolic blood pressure by >20 mm Hg in patients with treatment-resistant hypertension.
Why the study?
Does electrical activation of the carotid baroreflex reduce blood pressure in patients with treatment-resistant hypertension?
Does electrical activation of the carotid baroreflex reduce blood pressure in patients with treatment-resistant hypertension?
Electrical activation of the carotid baroreflex using modern implantable devices shows promise as a therapy for treatment-resistant hypertension, providing sustained blood pressure reductions.
May support baroreflex activation in resistant hypertension; leaves open its role pending randomized trials.
Electrical activation of the carotid baroreceptor system is an attractive therapy for the treatment of resistant hypertension. In the past, several attempts were made to directly activate the baroreceptor system in humans, but the method had to be restricted to a few selected patients. Adverse effects, the need for better electrical devices and better surgical techniques, and the lack of knowledge about long-term effects has greatly hampered developments in this area for many years. Recently, a new and promising device was evaluated in a multicenter feasibility trial, which showed a clinically and statistically significant reduction in office systolic blood pressure (>20 mm Hg). This reduction could be sustained for at least 2 years with an acceptable safety profile. In the future, this new device may stimulate further application of electrical activation of the carotid baroreflex in treatment-resistant hypertension.
No takes yet. Share an insight, caveat, or question.
Scheffers et al. (2010) conducted a review in Resistant hypertension. Electrical activation of the carotid baroreceptor system was evaluated. Electrical activation of the carotid baroreflex using a novel implantable device reduced office systolic blood pressure by >20 mm Hg in patients with treatment-resistant hypertension.