Key result
Invasive assessment links coronary microvascular dysfunction to hemodialysis-induced myocardial stunning without obstructive CAD.
Why the study?
Hemodialysis-induced myocardial stunning is common and linked to poor prognosis, but its pathophysiology is not fully understood.
Case Report (n=1)
No
Coronary microvascular dysfunction may play a crucial role in the pathophysiology of hemodialysis-induced myocardial stunning in the absence of obstructive coronary artery disease.
Coronary microvascular dysfunction may underlie hemodialysis-induced myocardial stunning without obstructive disease; this case report leaves open the need for prospective studies before clinical adoption.
Hemodialysis (HD)-induced myocardial stunning, characterized by transient left ventricular systolic dysfunction during HD, has been reported to be common and associated with a poor prognosis. However, the pathophysiology is not fully understood. We herein report a case of HD-induced myocardial stunning without obstructive coronary artery disease complicated by coronary microvascular dysfunction (CMD), suggesting that CMD plays a crucial role in the pathophysiology of this disease.
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Yokoi et al. (2023) conducted a case report in Hemodialysis-induced myocardial stunning (n=1). Hemodialysis was evaluated. In a patient with hemodialysis-induced myocardial stunning without obstructive coronary artery disease, invasive assessment revealed coronary microvascular dysfunction (CFR 1.1, IMR 23), suggesting its crucial pathophysiological role.
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