May 1, 1996British Journal of Haematology
Effects of desmopressin on circulating P‐selectin
Key result
Desmopressin infusion in healthy men resulted in a twofold increase in VWF-Ag levels but no significant change in plasma concentrations of cP-selectin.
Why the study?
Does desmopressin infusion increase circulating P-selectin in healthy men?
Population
8 healthy men
Comparison
Desmopressin 0.3 microgram/kg infused over 30 min vs Placebo infused over 30 min
Design
RCT, double-blind
Follow-up
24 h
Authors
Discussion
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Implication
Desmopressin does not raise cP-selectin despite VWF release; challenges Weibel-Palade bodies as primary source of circulating P-selectin.
Study Design
Type
RCT (n=8)
Blinding
Double-blind
Structured PICO
Does desmopressin infusion increase circulating P-selectin in healthy men?
P
Population
8 healthy men followed for 24 hours after infusion.
I
Intervention
Desmopressin 0.3 microgram/kg infused over 30 min
C
Comparator
Placebo infused over 30 min
O
Outcome
Plasma levels of circulating (c)P-selectin and VWF-Ag followed for 24 hsurrogate
Degranulation of Weibel-Palade bodies induced by desmopressin does not increase circulating P-selectin, suggesting other sources for its presence in plasma.
Cite This Study
Jilma et al. (1996) conducted an RCT in Healthy (n=8). Desmopressin (DDAVP) vs. Placebo was evaluated on Plasma concentrations of cP-selectin. Desmopressin infusion in healthy men resulted in a twofold increase in VWF-Ag levels but no significant change in plasma concentrations of cP-selectin.