Why the study?
Does bepridil improve atrial electrical remodeling in a canine rapid atrial stimulation model?
Does bepridil improve atrial electrical remodeling in a canine rapid atrial stimulation model?
Bepridil exerts an anti-electrical remodeling effect in a canine model of rapid atrial pacing, but this effect is less pronounced in the left atrium compared to the right atrium.
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Bepridil's inhomogeneous anti-remodeling effects in canine AF warrant caution in translation; leaves open atrium-specific mechanisms for targeted research.
Fukaya et al. (2008) studied this question.
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