Key result
Myocardial infarction in rats led to a 4.5- to 5.0-fold increase in Gi-2 alpha and a 3.4- to 8.2-fold increase in Gs alpha protein concentrations in border and scar regions compared to controls.
Population
Sprague-Dawley rats with myocardial infarction produced by ligation of the left coronary artery, evaluated…
Comparison
Myocardial infarction via left coronary artery… vs Sham-operated controls
Design
Preclinical
Follow-up
8 weeks
Authors
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Altered G-protein expression may contribute to post-MI scar remodeling; leaves open whether targeting Gi-2 or Gs alpha affects human outcomes.
In a rat model of post-MI heart failure, Gi-2 alpha and Gs alpha expression is markedly increased in myofibroblasts of the infarct scar and border zone myocytes, suggesting involvement in chronic scar remodeling.
David Peterson (1999) studied Myocardial infarction and heart failure. Myocardial infarction (left coronary artery ligation) vs. Sham-operated controls was evaluated on Gi-2 alpha and Gs alpha protein concentration, localization and mRNA abundance. Myocardial infarction in rats led to a 4.5- to 5.0-fold increase in Gi-2 alpha and a 3.4- to 8.2-fold increase in Gs alpha protein concentrations in border and scar regions compared to controls.
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