Key result
Surgical excision and radiotherapy were used to treat a 44-year-old woman with cerebellar malignant fibrous histiocytoma, a rare tumor with a median survival time of 27 months.
Case Report (n=1)
Malignant fibrous histiocytoma of the cerebellum is extremely rare and carries a poor prognosis, with total excision and radiotherapy appearing to be the best available treatment approach.
Single case supports excision plus radiotherapy for rare cerebellar MFH; leaves open survival benefit without controlled data.
OBJECTIVE AND IMPORTANCE: Malignant fibrous histiocytoma in the central nervous system is uncommon. Fewer than 70 cases have been documented and, to the best of our knowledge, this is the first case arising from the cerebellum. CLINICAL PRESENTATION: A 44-year-old woman presented with headaches, vomiting, and dizziness. A neurological examination revealed right cerebellar syndrome. Brain computed tomographic scans revealed an isodense tumor in the right cerebellar hemisphere. The breast ultrasonographic, bone scintigraphic, and thoracoabdominal computed tomographic findings were normal. INTERVENTION: The patient was surgically treated. The tumor recurred 1.5 months later, demonstrating hemorrhagic characteristics on brain computed tomographic scans. The patient underwent a second operation, followed by radiotherapy. CONCLUSION: Malignant fibrous histiocytoma is still a controversial entity, and the lack of specific criteria means that it must be diagnosed via the process of elimination. With currently available therapy, our review can provide only a very poor prognosis. The median survival time was 27 months. In attempts to develop better therapeutic strategies, total excision and radiotherapy seem to represent the best treatment approach.
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Hamlat et al. (2004) conducted a case report in Cerebellar Malignant Fibrous Histiocytoma (n=1). Surgical excision and radiotherapy was evaluated on Survival time. Surgical excision and radiotherapy were used to treat a 44-year-old woman with cerebellar malignant fibrous histiocytoma, a rare tumor with a median survival time of 27 months.
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