Key result
Extensive surgical removal of the tumor and bone followed by 50 Gy radiation therapy successfully treated a rare malignant fibrous histiocytoma of the skull, leaving the patient asymptomatic.
Case Report (n=1)
No
Malignant fibrous histiocytoma can rarely arise primarily from the skull and can be managed with extensive surgical resection and radiation therapy.
Supports resection plus radiation for rare skull MFH; leaves open optimal protocols in larger series.
A 45-year-old male presented with a large calvarial mass caused by a malignant fibrous histiocytoma arising primarily from the frontal bone and extending into the intracranial space. Magnetic resonance imaging revealed a well-demarcated, mottled enhanced bulky tumor with several low-signal separations. He underwent extensive tumor and bone removal, followed by radiation therapy. Histological examination showed pleomorphic spindle cells in a storiform pattern. The tissue stained positive for alpha-1-antitrypsin and alpha-1-antichymotrypsin by immunohistochemical techniques.
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Hatashita et al. (1992) conducted a case report in Malignant fibrous histiocytoma in the skull (n=1). Tumor and bone removal followed by radiation therapy was evaluated on Clinical outcome. Extensive surgical removal of the tumor and bone followed by 50 Gy radiation therapy successfully treated a rare malignant fibrous histiocytoma of the skull, leaving the patient asymptomatic.
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