Key result
Clazosentan is linked to greater reduction in acute CSF interleukin-6 after subarachnoid hemorrhage vs. fasudil.
Why the study?
The effects of clazosentan on cytokine and chemokine profiles in cerebrospinal fluid after subarachnoid hemorrhage remain unclear.
Does clazosentan alter the expression profile of inflammatory cytokines and chemokines in cerebrospinal fluid compared to fasudil hydrochloride in patients with aneurysmal subarachnoid hemorrhage?
Observational (n=22)
No
Does clazosentan alter the expression profile of inflammatory cytokines and chemokines in cerebrospinal fluid compared to fasudil hydrochloride in patients with aneurysmal subarachnoid hemorrhage?
Clazosentan suppresses early IL-6 expression in the cerebrospinal fluid following subarachnoid hemorrhage, offering a mechanistic explanation for its anti-inflammatory effects and prevention of cerebral vasospasm.
Clazosentan-associated CSF IL-6 suppression after subarachnoid hemorrhage is hypothesis-generating; larger trials needed to link this to clinical outcomes.
Clazosentan (CLA), an endothelin-A receptor antagonist, is used to prevent cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). Although its efficacy has been demonstrated in large-scale clinical trials, the effects of CLA on cytokine and chemokine profiles in cerebrospinal fluid (CSF) after SAH remain unclear. Twenty-two patients with SAH were enrolled. Ten patients received fasudil hydrochloride (FH), a Rho kinase inhibitor, and 12 received CLA. CSF samples were collected on days 1, 3, 5, 7, 10, and 14. Concentrations of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), interferon-γ-inducible protein-10 (IP-10), and monokine induced by interferon-γ (MIG) were measured using enzyme-linked immunosorbent assay. IL-6 levels were significantly suppressed during the acute phase in the CLA group compared with the FH group, whereas MCP-1 levels were upregulated on day 1. The peak expression of IP-10 and MIG was delayed in the CLA group relative to the FH group. A strong correlation between IP-10 and MIG was observed on day 5 in the FH group and on day 7 in the CLA group. CLA suppressed IL-6 expression during the acute phase, which may contribute to delayed upregulation of IP-10 and MIG. Suppression of IL-6 may represent a key mechanism underlying the anti-inflammatory effects of CLA following SAH.
No takes yet. Share an insight, caveat, or question.
Inomo et al. (2026) conducted an observational in Aneurysmal subarachnoid hemorrhage (n=22). Clazosentan vs. Fasudil hydrochloride was evaluated on Interleukin-6 (IL-6) concentration in cerebrospinal fluid during the acute phase (days 1-5). Clazosentan significantly suppressed interleukin-6 expression in the cerebrospinal fluid during the acute phase after subarachnoid hemorrhage compared to fasudil hydrochloride.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: