Key result
Following subarachnoid hemorrhage, cerebrospinal fluid IL-6 concentrations increased to over 1000 times control levels during the acute stage, followed by sequential peaks in MCP-1, IP-10, and MIG.
Population
10 patients with subarachnoid hemorrhage from anterior circulation aneurysms, and controls with unruptured…
Design
Cohort
Follow-up
14 days
Authors
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Post-SAH CSF cytokine timelines highlight neuroinflammatory targets; leaves open whether modulating IL-6 or MCP-1 improves outcomes.
Observational (n=15)
No
p-value: p=<0.05
Sequential expression of inflammatory cytokines in CSF after SAH suggests a dynamic inflammatory response that may be linked to delayed ischemic neurological deficits.
Niwa et al. (2016) conducted an observational in Subarachnoid hemorrhage (n=15). Subarachnoid hemorrhage vs. Unruptured aneurysms was evaluated on Cerebrospinal fluid concentration of IL-6 during the acute stage (p=<0.05). Following subarachnoid hemorrhage, cerebrospinal fluid IL-6 concentrations increased to over 1000 times control levels during the acute stage, followed by sequential peaks in MCP-1, IP-10, and MIG.
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