Key result
Elevated serum levels of IL-6 at 24-48 hours after subarachnoid hemorrhage were independently associated with poor functional outcomes at 3 months (OR 1.13 per 1 pg/mL increase).
Why the study?
Inflammation has been implicated in delayed cerebral ischemia (DCI) and poor outcomes after subarachnoid hemorrhage (SAH), but identifying cytokine patterns could provide insight into underlying processes amenable to interventions.
Population
60 patients with acute non-traumatic SAH
Comparison
Cytokine patterns across four time periods after SAH associated with DCI and poor functional outcomes
Design
Prospective cohort study
Follow-up
3 months
Authors
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May aid early prognostication after subarachnoid hemorrhage; hypothesis-generating for IL-6–targeted interventions.
Observational (n=60)
No
Odds Ratio: 1.13 (95% CI 1.018–1.257)
Specific serum cytokine patterns in early subarachnoid hemorrhage, including elevated PDGF-ABBB, CCL5, IL-6, and MCP-1, are associated with the development of delayed cerebral ischemia and poor functional outcomes at 3 months.
Ahn et al. (2019) conducted an observational in Acute non-traumatic subarachnoid hemorrhage (n=60). Elevated serum IL-6 levels (24-48 hours post-SAH) vs. Lower serum IL-6 levels was evaluated on Poor functional outcome at 3 months (mRS 3-6) (OR 1.13, 95% CI 1.018-1.257). Elevated serum levels of IL-6 at 24-48 hours after subarachnoid hemorrhage were independently associated with poor functional outcomes at 3 months (OR 1.13 per 1 pg/mL increase).
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