Key result
Glucose regulation linked to divergent renal sinus fat changes in South Asian versus West European patients.
Why the study?
Ethnic differences in diabetic kidney disease progression remain unclear, prompting evaluation of whether glucose-lowering treatment and liraglutide affect MRI-quantified renal sinus fat differently in West Europeans versus South Asians.
Does glucose-lowering treatment change MRI-quantified renal sinus fat volume differently in West European compared to South Asian patients with type 2 diabetes?
Population
Ninety-three patients with type 2 diabetes mellitus (47 West Europeans and 46 South Asians)
Comparison
West Europeans vs South Asians, and liraglutide vs placebo
Design
Retrospective study
Authors
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Ethnic differences in renal sinus fat response warrant no practice change; leaves open renal outcome implications and needs prospective trials.
Observational (n=93)
Does glucose-lowering treatment change MRI-quantified renal sinus fat volume differently in West European compared to South Asian patients with type 2 diabetes?
Absolute Event Rate: 5% vs -7.6%
Renal sinus fat accumulation responds differently to glucose regulation depending on ethnicity, decreasing in South Asian patients but increasing in West European patients.
Lin et al. (2023) conducted an observational in Type 2 diabetes mellitus (n=93). West European ethnicity vs. South Asian ethnicity was evaluated on Change in renal sinus fat volume (Δ%). Renal sinus fat accumulation in response to glucose regulation differed significantly by ethnicity, increasing by 5.0% in West European patients and decreasing by 7.6% in South Asian patients.
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