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February 19, 2020PLoS ONEOpen Access

Renal and renal sinus fat volumes as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

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Why the study?

It was hypothesized that MRI-based renal compartment volumes, especially renal sinus fat as perivascular fat tissue, increase with glucose intolerance and relate to cardiometabolic biomarkers.

Does glucose intolerance (prediabetes and diabetes) associate with increased renal and renal sinus fat volumes compared to normal glucose tolerance?

Population

366 normoglycemic participants or individuals with prediabetes or diabetes

Comparison

Normoglycemia vs prediabetes vs diabetes

Design

Cross-sectional MRI study

Authors

MNMike NotohamiprodjoUniversity of TübingenMGMartin GoepfertLMU KlinikumSWSusanne WillProcter & Gamble (Germany)

Discussion

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Overview

May indicate early renal remodeling in glucose intolerance; cross-sectional data leave causality and prognostic utility open.

Key Points

  • This study aims to examine the relationship between renal compartment volumes and glycemic status in individuals with prediabetes and diabetes.
  • Analyzed MRI-based renal volumes in N=366 individuals (normoglycemic, prediabetic, diabetic).
  • Employed coronal T1w dual-echo Dixon and T2w fast spin echo sequences for imaging.
  • Used linear regression models to evaluate associations between glycemic status and renal volumes.
  • Renal volume increased significantly across normoglycemic (280.3 ml), prediabetic (303.7 ml), and diabetic (320.6 ml) groups (p < 0.001).
  • Prediabetes was associated with increased renal sinus volume (β = 10.1, p < 0.01); diabetes also showed significant correlations.
  • Hypertension was linked to higher sinus volume (β = 3.7, p < 0.05) and fat volume (β = 3.0, p < 0.05).

Structured PICO

Does glucose intolerance (prediabetes and diabetes) associate with increased renal and renal sinus fat volumes compared to normal glucose tolerance?

P
Population
366 participants including normoglycemic (N=230), prediabetes (N=87), and diabetes (N=49) determined by Oral Glucose Tolerance Test.
I
Intervention
Prediabetes and diabetes (impaired glycemic status)
C
Comparator
Normoglycemic controls
O
Outcome
Renal volume, renal sinus volume, and renal sinus fat quantified by whole-body 3 Tesla MRIsurrogate

Renal volume and renal sinus fat volume increase significantly in prediabetic and diabetic subjects, suggesting renal sinus fat is an early imaging biomarker of metabolic disease.

Cite This Study

Notohamiprodjo et al. (2020) studied this question.

synapsesocial.com/papers/6a1e89b040bc8a3dd76908cfhttps://doi.org/10.1371/journal.pone.0216635
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Renal Sinus Adipose Tissue in Obesity-induced Renal Injury2016 · 31 citations
  2. 2Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study2018 · 46 citations
  3. 3Phenotypic Multiorgan Involvement of Subclinical Disease as Quantified by Magnetic Resonance Imaging in Subjects With Prediabetes, Diabetes, and Normal Glucose Tolerance2018 · 10 citations
  4. 4Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools2017 · 284 citations
  5. 5Association of Renal Insufficiency with Treatment and Outcomes after Myocardial Infarction in Elderly Patients2002 · 563 citations