Key result
Type 2 diabetes is linked to ~20% higher renal sinus fat volume vs. healthy controls.
Why the study?
This study was conducted to compare MRI-quantified renal parenchymal and renal sinus fat volumes between patients with type 2 diabetes mellitus and non-diabetic controls, and to evaluate the association between renal sinus fat volume and metabolic clinical indicators.
Does type 2 diabetes mellitus affect renal parenchymal volume and renal sinus fat volume measured by MRI compared to non-diabetic controls?
Case-Control (n=120)
No
Does type 2 diabetes mellitus affect renal parenchymal volume and renal sinus fat volume measured by MRI compared to non-diabetic controls?
Absolute Event Rate: 18% vs 15%
p-value: p=0.001
Patients with type 2 diabetes mellitus have significantly higher MRI-measured renal sinus fat volume and renal parenchymal volume than non-diabetic controls, suggesting renal sinus fat volume may serve as an indicator of metabolic risk.
Supports renal sinus fat as potential metabolic risk marker in T2DM; leaves open prognostic value and causal links.
Introduction : This study compared renal parenchyma volume and the renal sinus (hilus) fat volume between patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls using MRI. Aim : Additionally, we evaluate the association between renal sinus fat volume and metabolic clinical indicators. Materials and methods : A prospective study was conducted involving 120 participants (healthy controls and patients with T2DM). Abdominal MRI was performed using a 1.5-Tesla scanner (Magnetom Essenza, Siemens Healthcare) following standard protocols. Kidney assessment included localizer sequences and 3D axial T1 VIBE Dixon imaging. Semi-automatic segmentation with thresholding was used to quantify renal parenchymal volume and renal sinus fat volume. Results : Renal sinus fat volume (18.0±6.0 cm³ vs. 15.0±3.8 cm³, p =0.001) and renal parenchymal volume (153.3±26.0 cm³ vs. 139.8±17.1 cm³, p =0.001) were significantly higher in patients with T2DM than in healthy individuals. Conclusion : T2DM is associated with increased renal sinus fat volume and renal parenchymal volume compared with non-diabetic controls. Renal sinus fat volume may serve as a useful indicator of metabolic risk.
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Pavadai et al. (2026) conducted a case-control in Type 2 diabetes mellitus (n=120). Type 2 diabetes mellitus vs. Healthy non-diabetic controls was evaluated on Renal sinus fat volume (cm³) (p=0.001). Type 2 diabetes mellitus was associated with significantly higher renal sinus fat volume (18.0 vs. 15.0 cm³, p=0.001) and renal parenchymal volume (153.3 vs. 139.8 cm³, p=0.001) than healthy controls.
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