Why the study?
Does acute furosemide stimulation improve the predictive value of renal venous plasma renin activity measurements for lateralization in hypertensive patients?
Does acute furosemide stimulation improve the predictive value of renal venous plasma renin activity measurements for lateralization in hypertensive patients?
Acute stimulation of renin by furosemide does not improve, and may worsen, the predictive value of renal venous renin measurements for lateralizing renovascular hypertension.
Furosemide stimulation may not aid renal vein renin lateralization; leaves open optimal protocols for renovascular hypertension evaluation.
A control study comparing plasma renin activity (PRA) in the renal vein and the inferior vena cava was performed in 50 hypertensive patients before and after furosemide stimulation. In unilateral renal arterial stenosis, furosemide was found to stimulate secretion by the normal kidney more than by the ischemic kidney. When a renal venin PRA ratio of 1.5 or higher was used for lateralization, rates of 30% false-negatives and 60% false-positive resulted. Acute stimulation of renin by furosemide does not increase the predictive value of renal venous renin measurements and may actually result in a higher percentage of false-negatives.
No takes yet. Share an insight, caveat, or question.
Chuang et al. (1979) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: