Key result
Test-retest analysis defines ~3 mL/min/kg as the minimal meaningful change for VO2peak post-cardiac event.
Why the study?
Criteria for assessing improvements in key aerobic function parameters at the individual level are not established in patients with cardiovascular disease.
Observational (n=66)
This study establishes minimal meaningful change cutoffs using reliable change indices for key aerobic parameters (V˙o2peak, RCP, θLT) to better assess exercise training efficacy in cardiovascular disease patients.
May aid interpretation of VO2peak changes in cardiac rehab; extends reliability data but leaves open prospective validation.
PURPOSE: Improving aerobic fitness through exercise training is recommended for the treatment of cardiovascular disease (CVD). However, strong justifications for the criteria of assessing improvement in key parameters of aerobic function including estimated lactate threshold (θ LT ), respiratory compensation point (RCP), and peak oxygen uptake (V˙ o2peak ) at the individual level are not established. We applied reliable change index (RCI) statistics to determine minimal meaningful change (MMC RCI ) cutoffs of θ LT , RCP, and V˙ o2peak for individual patients with CVD. METHODS: Sixty-six stable patients post-cardiac event performed three exhaustive treadmill-based incremental exercise tests (modified Bruce) ∼1 wk apart (T1-T3). Breath-by-breath gas exchange and ventilatory variables were measured by metabolic cart and used to identify θ LT , RCP, and V˙ o2peak . Using test-retest reliability and mean difference scores to estimate error and test practice/exposure, respectively, MMC RCI values were calculated for V˙ o2 (mL·min -1. kg -1 ) at θ LT , RCP, and V˙ o2peak . RESULTS: There were no significant between-trial differences in V˙ o2 at θ LT ( P = .78), RCP ( P = .08), or V˙ o2peak ( P = .74) and each variable exhibited excellent test-retest variability (intraclass correlation: 0.97, 0.98, and 0.99; coefficient of variation: 6.5, 5.4, and 4.9% for θ LT , RCP, and V˙ o2peak , respectively). Derived from comparing T1-T2, T1-T3, and T2-T3, the MMC RCI for θ LT were 3.91, 3.56, and 2.64 mL·min -1. kg -1 ; 4.01, 2.80, and 2.79 mL·min -1. kg -1 for RCP; and 3.61, 3.83, and 2.81 mL·min -1. kg -1 for V˙ o2peak . For each variable, MMC RCI scores were lowest for T2-T3 comparisons. CONCLUSION: These MMC RCI scores may be used to establish cutoff criteria for determining meaningful changes for interventions designed to improve aerobic function in individuals with CVD.
No takes yet. Share an insight, caveat, or question.
Faricier et al. (2023) conducted an observational in Cardiovascular disease (n=66). Treadmill-based incremental exercise tests was evaluated on Minimal meaningful change (MMC RCI) cutoffs of θ LT, RCP, and V˙o2peak. In stable patients post-cardiac event, the minimal meaningful change for VO2peak derived from test-retest reliability ranged from 2.81 to 3.83 mL·min-1·kg-1.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: