Key result
Hyperpnea-induced hypocapnia significantly prolonged the oxygen uptake time constant at exercise onset compared to normocapnia (37 vs 28 s) and eupnea (21 s, P<0.05).
Why the study?
Does hyperpnea-induced hypocapnia and normocapnia delay the oxygen uptake response to exercise onset in male subjects?
Does hyperpnea-induced hypocapnia and normocapnia delay the oxygen uptake response to exercise onset in male subjects?
Absolute Event Rate: 37% vs 21%
p-value: p=<0.05
Respiratory alkalosis delays the kinetics of oxygen diffusion in active muscle, supporting the role of hemoglobin-O2 offloading in setting V˙o2 kinetics at exercise onset.
Authors
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May slow VO2 kinetics via alkalosis; hypothesis-generating for O2 offloading mechanisms with no current clinical implications.
Hayashi et al. (1999) studied this question. Hyperpnea (hypocapnia and normocapnia) vs. Eupnea (control) was evaluated on Time constant of oxygen uptake (VO2) (p=<0.05). Hyperpnea-induced hypocapnia significantly prolonged the oxygen uptake time constant at exercise onset compared to normocapnia (37 vs 28 s) and eupnea (21 s, P<0.05).
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