July 13, 2013Experimental PhysiologyOpen Access

Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation

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Population

7 healthy men

Comparison

8 min cycling transitions during moderate… vs 8 min cycling transitions during normoxia

Authors

TBT. Scott BowenHeart Failure / Cardiomyopathy HRHarry B. RossiterPreventive Cardiology ABAlan P. BensonUniversity of Leeds

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether microvascular O2 mismatch limits VO2 kinetics in broader populations.

Structured PICO

Population

7 healthy men

Intervention

8 min cycling transitions during moderate hypoxia and severe hypoxia

Comparator

8 min cycling transitions during normoxia

Outcome

Pulmonary O2 uptake kinetics (phase II time constant) and absolute skeletal muscle deoxygenation [HHb] (transient peak and spatial distribution)surrogate

Slowed oxidative energy provision at the onset of exercise correlates with transient skeletal muscle deoxygenation peak and reduced spatial distribution, suggesting an absolute mismatch of microvascular O2 delivery and consumption limits kinetics.

Cite This Study

Bowen et al. (2013) studied this question.

synapsesocial.com/papers/6a7045c9febe604dd7090e00 https://doi.org/10.1113/expphysiol.2013.073270

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Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider