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December 22, 2025Cell Reports Medicine13 citationsOpen Access

Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

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KCKalyani ChaubeyEVEdwin Vázquez-RosaSTSunil Jamuna Tripathi

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Abstract

homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

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Cite This Study

Chaubey et al. (2025) studied this question.

synapsesocial.com/papers/6a203bf68753b605d8b5d0a7https://doi.org/10.1016/j.xcrm.2025.102535
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