Key result
Low-dose aspirin added to antihypertensives linked to ~36-point lower preeclampsia rate in hypertensive pregnancy.
Why the study?
Hypertensive disorders during pregnancy cause major maternal and fetal complications, but indications for aspirin use in this setting remain a subject of concern.
Does daily low-dose aspirin alongside antihypertensives prevent eclampsia in pregnant women with hypertensive disorders?
Observational (n=100)
No
Does daily low-dose aspirin alongside antihypertensives prevent eclampsia in pregnant women with hypertensive disorders?
Daily low-dose aspirin alongside antihypertensive therapy in pregnant women with hypertensive disorders is associated with the prevention of eclampsia.
Answers are grounded in this paper and cite their sources.
Supports adjunctive aspirin consideration; hypothesis-generating and should not change practice without RCTs.
Background: Hypertensive disorders represent major causes of maternal and fetal complications. It includes a range of conditions, most notably preeclampsia. Aspirin is a well-accepted therapy for the primary and secondary prevention of cardiovascular events. The indications for the use of aspirin during pregnancy are, however, the subject of much concern. This study aimed to assess the clinical characteristics from the benefits of daily low-dose aspirin administration alongside antihypertensive in pregnant women with different hypertensive disorders. Materials and Methods: A retrospective observational study was carried out on pregnant women during their routine visit to the obstetric clinic at Baghdad Teaching Hospital. Patients diagnosed during pregnancy with different hypertensive disorders on the prescription of antihypertensive medication with or without daily low-dose aspirin administration were selected. Data were collected to structure a detailed assessment regarding the patients’ demographic, gestational, and medical records. Results: Methyldopa was the main antihypertensive agent (98%). Among pregnant women with daily aspirin use, 68% had gestational hypertension, 24% had preeclampsia alongside proteinuria (P = 0.0001), the frequency of daily dose intake of methyldopa (250 mg) tablet (two vs. three times) was significant (P = 0.0001). All pregnant women within the group of daily low-dose aspirin were safe from the incidence of eclampsia (P = 0.0001). Conclusion: This study provides intriguing evidence for the benefits of daily low-dose aspirin use during pregnancy as it is considered as a simple protective measure from serious maternal complications of hypertensive disorders, where these complications continue to affect maternal health long after delivery.
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Al‐Taie et al. (2019) conducted an observational in Hypertensive pregnancy disorders (n=100). Daily low-dose aspirin vs. Antihypertensive medication only (no daily low-dose aspirin) was evaluated on Incidence of preeclampsia (p=0.0001). Daily low-dose aspirin administration alongside antihypertensives in pregnant women with hypertensive disorders was associated with a lower incidence of preeclampsia.
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